Read e-book online One Renegade Cell: The Quest For The Origin Of Cancer PDF

By Robert A. Weinberg

ISBN-10: 1780227787

ISBN-13: 9781780227788

Melanoma learn has reached an incredible turning element. the quantity of knowledge accrued some time past 20 years in regards to the origins of the ailment is the ultimate within the background of biomedical learn. during this ebook one in every of America's most outstanding scientists explains to the final reader the step by step approach during which cancers come up, and extra importantly, how they spread.

Robert Weinberg explains how basic genes keep an eye on the normal development of the phone, how, of their mutated shape, they permit cancers to come up, and why those genes have such life-and-death energy over us. Drawing from details that easily used to be no longer to be had until eventually lately, One Renegade Cell explains this insidious affliction as no different publication as ever been in a position to do.

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Additional resources for One Renegade Cell: The Quest For The Origin Of Cancer (Science Masters)

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J Am Geriatr Soc 2004;52(3):423–427. 23. Makipour S, Kanapuru B, Ershler WB. Unexplained anemia in the elderly. Semin Hematol 2008;45(4):250–254. REFERENCES 27 24. Izaks GJ, Westendorp RG, Knook DL. The definition of anemia in older persons. JAMA. 1999;281(18):1714–1717. 25. Balducci L. Aging, frailty, and chemotherapy. Cancer Control 2007;14(1):7–12. 26. Balducci L, Corcoran MB. Antineoplastic chemotherapy of the older cancer patient. Hematol Oncol Clin North Am 2000;14(1):193–212, x–xi. 27. Balducci L, Extermann M.

Longo VD, Finch CE. Evolutionary medicine: From dwarf model systems to healthy centenarians? Science 2003;299(5611):1342–1346. 112. Olumi AF, Grossfeld GD, Hayward SW, Carroll PR, Tlsty TD, Cunha GR. Carcinomaassociated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res 1999;59(19):5002–5011. 113. Park CC, Bissell MJ, Barcellos-Hoff MH. The influence of the microenvironment on the malignant phenotype. Mol Med Today 2000;6(8):324–329. 114. Parrinello S, Coppe JP, Krtolica A, Campisi J.

For example, skin epithelium, and liver and lymphoid tissues, but not nervous or muscular tissues, show increased susceptibility to late-stage carcinogens in older rodents [148,149]. Similarly, the incidence of melanoma and mesothelioma in humans demonstrates an age-related plateau, suggesting that these tissues are not more susceptible to late-stage carcinogens [145–147]. Other age-related factors that may increase cancer risk include age-impaired DNA repair mechanisms and decreased carcinogen catabolism [149,150].

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One Renegade Cell: The Quest For The Origin Of Cancer (Science Masters) by Robert A. Weinberg

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