By John W. Duckett M.D. (auth.), Stephen A. Zderic (eds.)
This convention and monograph have been the results of many collective efforts. the total idea used to be formulated one early Wednesday morning at our weekly examine assembly at kid's health facility in our department of urology. we now have been such a lot lucky to have an in depth collaboration with Bob Levin, Ed Macarak, and Pam Howard who've helped steer the process our division's becoming curiosity in uncomplicated technological know-how. At our weekly conferences our laboratory fellow will summarize their present paintings. different ongoing parts of research in our labs and in different places are mentioned. we now have constantly made an attempt to aim and comprehend what different teams are doing who're operating within the sector of bladder soft muscle examine. It happened to us that how to relatively comprehend what every body operating during this box was once doing will be to sponsor a 2-day assembly the place lets all assemble to debate our ongoing paintings. an immense issue of the yearly assembly of the yankee Urologic organization or the urology portion of the yank Academy of Pediatrics is that the scientfic classes are restricted as those are supposed to be basically scientific conferences (as they need to be). hence the assumption of a gathering dedicated completely to analyze concerning the urinary bladder had nice charm. as well as taking into account longer shows than the traditional five to 7 mins, each attempt will be made to motivate a discussion among the presenters and the audience.
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Extra info for Muscle, Matrix, and Bladder Function
1991) We studied the velocity of contraction of muscle strips in vitro which had been obstructed and compared the results to the weight of the bladder. Using phase plot analysis, we found that the velocity of contraction, an indicator of contractile efficiency, decreased as the weight of the bladder increased. , 1993) . Once it became clear that disordeted cell size shape and number was associated with decreased contractility and urodynamic performance, we began to look for underlying mechanisms.
Uvelius, B. and Hellstrand, P. , 1980, Effects of phasic and tonic activation on contraction dynamics in smooth muscle. Acta Physiol Scand 109:399-406. R. L. , 1987, Energy expenditure of longitudinal smooth muscle of rabbit urinary bladder. Am. J. Physiol. 252:C88-C96. 39 THE NEURONAL RESPONSE TO BLADDER OUTLET OBSTRUCTION, A ROLE FOR NGF Mary C. Dupont, Katarina Persson, John Spitsbergen, Jeremy B. Tuttle, and William D. Steers Department of Urology, University of Virginia, Charlottesville, Virginia INTRODUCTION Theories of Irritative Voiding Symptoms in Response to Obstruction Bladder outflow obstruction can give rise to irritative voiding symptoms characterized by urinary frequency, urgency and nocturia.
This pointed to an abnormality of channel behavior and a decrease in membrane resistance, but in order to study this more fully, one would have to use the more modern method of patch clamp analysis, potentially very interesting experiments still waiting to be done. Therefore, we left these findings to pursue studies of the other passive properties, space and time constants, which require the use of multi syncytial preparations. When current is introduced into a cell it is depolarized towards the threshold at which an action potential (AP) arises from self-propagating channel activation.
Muscle, Matrix, and Bladder Function by John W. Duckett M.D. (auth.), Stephen A. Zderic (eds.)