By Andrew Eisen, Pamela J. Shaw MD
This quantity within the instruction manual of scientific Neurology (Series Editors: Michael J. Aminoff, division of Neurology, college of California, San Francisco, united states; FranÃ§ois Boller, Bethesda, united states; Dick F. Swaab, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands) on motor neuron issues and comparable ailments bargains with the impressive advances that experience occured in recent times within the knowing of those problems and their underlying molecular pathogenesis. An account is additionally supplied of the final scientific positive factors and mangement of those devasting problems, with the intention to be useful to all those that take care of sufferers plagued by them.
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Additional info for Motor Neuron Disorders and Related Diseases: Handbook of Clinical Neurology Vol 82
Primate red nucleus discharge encodes the dynamics of limb muscle activity. J Neurophysiol 80: 59–70. Miller LE, van Kan PL, Sinkjaer T, Andersen T, Harris GD, Houk JC (1993). Correlation of primate red nucleus discharge with muscle activity during free-form arm movements. J Physiol (Lond) 469: 213–243. Moran DW, Schwartz AB (1999). Motor cortical activity during drawing movements: population representation during spiral tracing. J Neurophysiol 82: 2693–2704. Morecraft RJ, Herrick JL, Stilwell-Morecraft KS, Louie JL, Schroeder CM, Ottenbacher JG, Schoolfield MW (2002).
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Similar deficits in making fine adjustments to gross patterns can be observed in more proximal movements as well (Tower, 1940). Sparing of even a small fraction of the pyramidal fibers results in superior recovery, even recovery of finger movements (Schwartzman, 1978). Substantially better recovery of function also is seen, paradoxically, in monkeys with bilateral pyramidal lesions (Tower, 1940; Lawrence and Kuypers, 1968a). Ambulation improves 29 toward normal, and the monkey also regains the ability to use both the upper and lower extremities to climb deftly, grasping with both the hands and the feet.
Motor Neuron Disorders and Related Diseases: Handbook of Clinical Neurology Vol 82 by Andrew Eisen, Pamela J. Shaw MD