By Chandan K. Sen
This paintings encapsulates the makes use of of miRNA throughout stem cells, developmental biology, tissue harm and tissue regeneration. specifically participants supply concentrated assurance of methodologies, intervention and tissue engineering.
Regulating nearly all organic methods, the genome’s 1048 encoded microRNAs seem to carry significant promise for the capability fix and regeneration of tissues and organs in destiny treatments. during this paintings, 50 specialists deal with key themes of this fast-emerging box. Concisely summarizing and comparing key findings rising from basic examine into translational program, they aspect to the present and destiny value of scientific study within the miRNA zone. insurance encompasses all significant elements of primary stem mobile and developmental biology, together with the makes use of of miRNA throughout fix and regeneration, and particular assurance of methodologies and interventions as they element in the direction of organ and tissue engineering
- Multi-colour textual content format with one hundred fifty color figures to demonstrate vital findings
- Take domestic messages encapsulate key classes all through text
- Short chapters provide concentrated dialogue and transparent ‘voice’
Read or Download MicroRNA in Regenerative Medicine PDF
Best bioinformatics books
This booklet constitutes the refereed court cases of the eleventh ecu convention on Evolutionary Computation, laptop studying and information Mining in Bioinformatics, EvoBIO 2013, held in Vienna, Austria, in April 2013, colocated with the Evo* 2013 occasions EuroGP, EvoCOP, EvoMUSART and EvoApplications. the ten revised complete papers provided including nine poster papers have been rigorously reviewed and chosen from various submissions.
Advances in pcs and biotechnology have had a big influence at the biomedical fields, with large effects for humanity. Correspondingly, new parts of likelihood and data are being constructed particularly to satisfy the wishes of this quarter. there's now a need for a textual content that introduces chance and facts within the bioinformatics context.
This e-book constitutes the refereed complaints of the Second foreign Bioinformatics learn and improvement convention, chicken 2008, held in Vienna, Austria in July 2008. The forty nine revised complete papers offered have been conscientiously reviewed and chosen. 30 papers are geared up in topical sections by means of eleven papers from the ALBIO workshop and eight papers from the PETRIN workshop.
With the particular genomic details that's now turning into to be had, now we have a plethora of information that permits researchers to handle questions in various parts. Genome-wide organization experiences (GWAS) became an important method of establish candidate areas linked to advanced illnesses in human drugs, construction features in agriculture, and edition in wild populations.
- Principles of Biomedical Informatics
- Protein Simulations
- Structural and Evolutionary Genomics, Volume 37: Natural Selection in Genome Evolution
- EMBOSS Developer's Guide: Bioinformatics Programming
Extra info for MicroRNA in Regenerative Medicine
Indeed, Dicer1-null ESCs do not fully down-regulate pluripotency markers and show alterations in the differentiation program . Several miRNAs are expressed preferentially in ESCs and help to maintain the ESC phenotype by rapid cell proliferation and cell cycle progression. ESCs are defined by a specific miRNA signature, and the majority of these miRNAs are transcribed from two clusters in the human genome: miR-371 and miR-302. 10 CONCLUSIONS AND FUTURE PERSPECTIVES Once considered as junk RNA not useful for the individual, miRNAs have now emerged as critical regulators of cell-to-systems biology.
Identification of clustered microRNAs using an ab initio prediction method. BMC Bioinformatics 2005;6:267.  Sheng Y, Engstrom PG, Lenhard B. Mammalian microRNA prediction through a support vector machine model of sequence and structure. PLoS One 2007;2:e946.  Tsai WC, Hsu PW, Lai TC, et al. MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma. Hepatology 2009;49:1571–82.  Thatcher E, Flynt A, Li N, et al. MiRNA expression analysis during normal zebrafish development and following inhibition of the Hedgehog and Notch signaling pathways.
Proc Natl Acad Sci USA 2008;105:10513–8.  Cullen BR. Transcription and processing of human microRNA precursors. Mol Cell 2004;16:861–5.  Chong MM, Zhang G, Cheloufi S, et al. Canonical and alternate functions of the microRNA biogenesis machinery. Genes Dev 2010;24:1951–60.  Yang JS, Lai EC. Alternative miRNA biogenesis pathways and the interpretation of core miRNA pathway mutants. Mol Cell 2011;43:892–903. 41 42 CHAPTER 1: MicroRNA Biogenesis in Regenerative Medicine  Ruby JG, Jan CH, Bartel DP.
MicroRNA in Regenerative Medicine by Chandan K. Sen