MicroRNA in Regenerative Medicine by Chandan K. Sen PDF

By Chandan K. Sen

ISBN-10: 0124055443

ISBN-13: 9780124055445

This paintings encapsulates the makes use of of miRNA throughout stem cells, developmental biology, tissue harm and tissue regeneration. specifically participants supply concentrated assurance of methodologies, intervention and tissue engineering.

Regulating nearly all organic methods, the genome’s 1048 encoded microRNAs seem to carry significant promise for the capability fix and regeneration of tissues and organs in destiny treatments. during this paintings, 50 specialists deal with key themes of this fast-emerging box. Concisely summarizing and comparing key findings rising from basic examine into translational program, they aspect to the present and destiny value of scientific study within the miRNA zone. insurance encompasses all significant elements of primary stem mobile and developmental biology, together with the makes use of of miRNA throughout fix and regeneration, and particular assurance of methodologies and interventions as they element in the direction of organ and tissue engineering

  • Multi-colour textual content format with one hundred fifty color figures to demonstrate vital findings
  • Take domestic messages encapsulate key classes all through text
  • Short chapters provide concentrated dialogue and transparent ‘voice’

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Extra info for MicroRNA in Regenerative Medicine

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Indeed, Dicer1-null ESCs do not fully down-regulate pluripotency markers and show alterations in the differentiation program [146]. Several miRNAs are expressed preferentially in ESCs and help to maintain the ESC phenotype by rapid cell proliferation and cell cycle progression. ESCs are defined by a specific miRNA signature, and the majority of these miRNAs are transcribed from two clusters in the human genome: miR-371 and miR-302. 10 CONCLUSIONS AND FUTURE PERSPECTIVES Once considered as junk RNA not useful for the individual, miRNAs have now emerged as critical regulators of cell-to-systems biology.

Identification of clustered microRNAs using an ab initio prediction method. BMC Bioinformatics 2005;6:267. [129] Sheng Y, Engstrom PG, Lenhard B. Mammalian microRNA prediction through a support vector machine model of sequence and structure. PLoS One 2007;2:e946. [130] Tsai WC, Hsu PW, Lai TC, et al. MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma. Hepatology 2009;49:1571–82. [131] Thatcher E, Flynt A, Li N, et al. MiRNA expression analysis during normal zebrafish development and following inhibition of the Hedgehog and Notch signaling pathways.

Proc Natl Acad Sci USA 2008;105:10513–8. [118] Cullen BR. Transcription and processing of human microRNA precursors. Mol Cell 2004;16:861–5. [119] Chong MM, Zhang G, Cheloufi S, et al. Canonical and alternate functions of the microRNA biogenesis machinery. Genes Dev 2010;24:1951–60. [120] Yang JS, Lai EC. Alternative miRNA biogenesis pathways and the interpretation of core miRNA pathway mutants. Mol Cell 2011;43:892–903. 41 42 CHAPTER 1: MicroRNA Biogenesis in Regenerative Medicine [121] Ruby JG, Jan CH, Bartel DP.

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MicroRNA in Regenerative Medicine by Chandan K. Sen

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