MicroRNA Cancer Regulation: Advanced Concepts, by Thalia A. Farazi, Jessica I. Hoell, Pavel Morozov (auth.), PDF

By Thalia A. Farazi, Jessica I. Hoell, Pavel Morozov (auth.), Ulf Schmitz, Olaf Wolkenhauer, Julio Vera (eds.)

ISBN-10: 9400755899

ISBN-13: 9789400755895

ISBN-10: 9400755902

ISBN-13: 9789400755901

This edited displays the present country of information concerning the position of microRNAs within the formation and development of sturdy tumours. the focus lies on computational equipment and purposes, including leading edge experimental thoughts which are used to technique all features of microRNA law in melanoma. we're yes that the emergence of high-throughput quantitative ideas will make this integrative strategy totally useful within the close to destiny. This ebook should be a source for researchers beginning out with melanoma microRNA examine, yet is usually meant for the skilled researcher who desires to comprise ideas and instruments from platforms biology and bioinformatics into his paintings. Bioinformaticians and modellers are supplied with a common viewpoint on microRNA biology in melanoma, and the cutting-edge in computational microRNA biology.

Show description

Read or Download MicroRNA Cancer Regulation: Advanced Concepts, Bioinformatics and Systems Biology Tools PDF

Best cancer books

Siddhartha Mukherjee's The Emperor of All Maladies: A Biography of Cancer PDF

Winner of the Pulitzer Prize, and now a documentary from Ken Burns on PBS, The Emperor of All Maladies is an impressive, profoundly humane “biography” of cancer—from its first documented appearances millions of years in the past during the epic battles within the 20th century to medication, keep watch over, and triumph over it to a thorough new knowing of its essence.

Download e-book for kindle: Targeted Drug Strategies for Cancer and Inflammation by Larry H. Matherly, Ndeye Diop-Bove (auth.), Ann L. Jackman,

The discoveries highlighted during this e-book parallel the emergence of cutting edge “molecular certain” small molecules and monoclonal antibodies, i. e. brokers that focus on proteins inside hugely activated sign transduction pathways that keep watch over proliferation. a few of the tumor-targeted options defined inside move the limits among what’s thought of to be “molecular distinctive” as opposed to traditional systemic treatment.

Mia K. Markey's Physics of Mammographic Imaging PDF

As a result of expanding variety of electronic mammograms and the arrival of recent types of 3-dimensional x-ray and other kinds of scientific imaging, mammography is present process a dramatic swap. to satisfy their tasks, scientific physicists needs to always renew their wisdom of advances in scientific imaging or radiation treatment, and has to be ready to operate on the intersection of those fields.

New PDF release: The Death of Cancer: After Fifty Years on the Front Lines of

Melanoma touches everybody’s existence in a single method or one other. yet such a lot folks comprehend little or no approximately how the affliction works, why we deal with it the way in which we do, and the personalities whose commitment acquired us the place we're this present day. for 50 years, Dr. Vincent T. DeVita Jr. has been a type of key gamers: he has held on the subject of each significant place within the box, and he built the 1st winning chemotherapy therapy for Hodgkin’s lymphoma, a step forward the yank Society of medical Oncologists has known as the pinnacle learn improve in part a century of chemotherapy.

Additional info for MicroRNA Cancer Regulation: Advanced Concepts, Bioinformatics and Systems Biology Tools

Example text

164. 165. 166. regulating glioblastoma survivorship. Proc Natl Acad Sci U S A 107:2183–2188 Cole KA, Attiyeh EF, Mosse YP et al (2008) A functional screen identifies miR-34a as a candidate neuroblastoma tumor suppressor gene. Mol Cancer Res 6:735–742 Li N, Fu H, Tie Y et al (2009) miR-34a inhibits migration and invasion by down-regulation of c-Met expression in human hepatocellular carcinoma cells. Cancer Lett 275:44–53 Gregory PA, Bracken CP, Bert AG et al (2008) MicroRNAs as regulators of epithelial-mesenchymal transition.

J Thorac Cardiovasc Surg 135:255–260; discussion 260 Iorio MV, Visone R, Di Leva G et al (2007) MicroRNA signatures in human ovarian cancer. Cancer Res 67:8699–8707 20 167. Negrini M, Calin GA (2008) Breast cancer metastasis: a microRNA story. Breast Cancer Res 10:203 168. Ferretti E, De Smaele E, Po A et al (2009) MicroRNA profiling in human medulloblastoma. Int J Cancer 124:568–577 169. Laios A, O’Toole S, Flavin R et al (2008) Potential role of miR-9 and miR-223 in recurrent ovarian cancer. Mol Cancer 7:35 170.

Furthermore, each miRNA can target more than one messenger RNA [36], and more than one miRNA can regulate a single target site. com/rna22. uni-bielefeld. il/pubs/ mir07/ 32 S. A. Calin 2 Bioinformatics, Non-coding RNAs and Its Possible Application in Personalized Medicine Most of these programs require some degree of sequence complementarity (commonly in the form of a seed of 6–8 nucleotides) as well as favorable free energy in the miRNA-target duplex, although it has been shown that free energy calculations do not have much impact on the accuracy of the program’s predictions [41].

Download PDF sample

MicroRNA Cancer Regulation: Advanced Concepts, Bioinformatics and Systems Biology Tools by Thalia A. Farazi, Jessica I. Hoell, Pavel Morozov (auth.), Ulf Schmitz, Olaf Wolkenhauer, Julio Vera (eds.)

by Mark

Rated 4.20 of 5 – based on 35 votes