By Thalia A. Farazi, Jessica I. Hoell, Pavel Morozov (auth.), Ulf Schmitz, Olaf Wolkenhauer, Julio Vera (eds.)
This edited displays the present country of information concerning the position of microRNAs within the formation and development of sturdy tumours. the focus lies on computational equipment and purposes, including leading edge experimental thoughts which are used to technique all features of microRNA law in melanoma. we're yes that the emergence of high-throughput quantitative ideas will make this integrative strategy totally useful within the close to destiny. This ebook should be a source for researchers beginning out with melanoma microRNA examine, yet is usually meant for the skilled researcher who desires to comprise ideas and instruments from platforms biology and bioinformatics into his paintings. Bioinformaticians and modellers are supplied with a common viewpoint on microRNA biology in melanoma, and the cutting-edge in computational microRNA biology.
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Additional info for MicroRNA Cancer Regulation: Advanced Concepts, Bioinformatics and Systems Biology Tools
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Furthermore, each miRNA can target more than one messenger RNA , and more than one miRNA can regulate a single target site. com/rna22. uni-bielefeld. il/pubs/ mir07/ 32 S. A. Calin 2 Bioinformatics, Non-coding RNAs and Its Possible Application in Personalized Medicine Most of these programs require some degree of sequence complementarity (commonly in the form of a seed of 6–8 nucleotides) as well as favorable free energy in the miRNA-target duplex, although it has been shown that free energy calculations do not have much impact on the accuracy of the program’s predictions .
MicroRNA Cancer Regulation: Advanced Concepts, Bioinformatics and Systems Biology Tools by Thalia A. Farazi, Jessica I. Hoell, Pavel Morozov (auth.), Ulf Schmitz, Olaf Wolkenhauer, Julio Vera (eds.)