Download e-book for kindle: Mechanisms of Cancer Metastasis: Potential Therapeutic by William E. Powers (auth.), Kenneth V. Honn, William E.

By William E. Powers (auth.), Kenneth V. Honn, William E. Powers, Bonnie F. Sloane (eds.)

ISBN-10: 1461296463

ISBN-13: 9781461296461

ISBN-10: 1461326354

ISBN-13: 9781461326359

The previous two decades have witnessed major advances within the remedy of melanoma by means of surgical procedure and radiation remedy. earnings with cytotoxic chemotherapy were even more modest. Of the nearly 900,000 newly clinically determined instances of melanoma every year, 50010 bring about loss of life of the sufferer. the first reason for those deaths is metastasis. even though the time period metastasis used to be first coined via Recamier in 1829, simply some time past ten years have there been in depth clinical investigations into the mechanisms during which tumor cells metastasize. What has emerged is a fancy strategy of host-tumor telephone interactions which has been termed the metastatic cascade. a result of complexity of the metastatic technique, the examine of metastasis is multifaceted and includes components of such parts as differentiation, en­ zymology, genetics, hematology, immunology, membrane biochemistry and molecular biology. the most important ambitions of this publication have been to give the latest advances in our knowing of the way tumor cells metastasize to secondary websites by way of the prime specialists within the biology of tumor invasion and metastasis. we are hoping that this booklet will bring about new suggestions for the therapy of subclinical metastatic melanoma. The chapters during this ebook tackle either the fundamental technological know-how of metastasis and strength scientific cures directed towards interruption of the metastatic cascade or towards eradication of subclinical metastases. Many appropriate themes were passed over because of area issues and therefore the themes integrated replicate the prej­ udices of the editors.

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Additional info for Mechanisms of Cancer Metastasis: Potential Therapeutic Implications

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The implications of its occurrence in the clinic would be far-reaching, and include: 1. The need to rethink accepted patterns of cross-resistance in the design of combination chemotherapy. Drugs such as adriamycin, vincristine, VP-16, and actinomycin-D cannot be considered to be unrelated in terms of potential cross-resistance. 20 2. The need to incorporate drug-resistant tumor models into drug screening systems in order to identify agents active against this type of cell. Table 5. Biochemical Mechanisms of Drug Resistance.

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Weiss L: The Cell Periphery, Metastasis and Other Contact Phenomena. North Holland, Amsterdam, pp. 292-393, 1967. Heppner GH, Dexter DL, Denocci T, Miller FR, Calabresi P: Heterogeneity in drug sensitivity among tumor cell subpopulations of a single mammary tumor. Cancer Res. 38:3758-3763, 1978. Nicolson GL: Generation of phenotypic diversity and progression in metastatic tumor cells. Cancer Metastasis Rev. 3:25-42, 1984. Weiss L: Metastasis: Differences between cancer cells in primary and secondary tumors.

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Mechanisms of Cancer Metastasis: Potential Therapeutic Implications by William E. Powers (auth.), Kenneth V. Honn, William E. Powers, Bonnie F. Sloane (eds.)


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