Download e-book for iPad: In Silico Immunology by Darren D.R. Flower, Jon Timmis

By Darren D.R. Flower, Jon Timmis

ISBN-10: 0387392386

ISBN-13: 9780387392387

Theoretical immunology is the appliance of mathematical modeling to various features of immunology. Immunoinformatics, the applying of computational informatics to the learn of immunological macromolecules, addresses questions in immunobiology and vaccinology, in addition to addressing problems with information administration, and will layout and enforce new experimental options. man made Immune structures (AIS) makes use of principles and ideas from immunology to lead and encourage new algorithms, info buildings, and software program development.

These 3 assorted disciplines are actually poised to engineer a paradigm shift from speculation- to data-driven learn, with new figuring out rising from the research of advanced datasets: theoretical immunology, immunoinformatics, and synthetic Immune structures (AIS). "in silico Immunology" will summarize those emergent disciplines and should deal with the difficulty of synergy because it indicates how those 3 are set to remodel immunological technological know-how and the way forward for wellbeing and fitness care.

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Extra info for In Silico Immunology

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The region on a macromolecule, which undertakes the recognition of an epitope, is called a paratope. In terms of the physical chemistry of binding, then we need think only of equal partners in a binding reaction. B cell epitopes are regions of a protein recognized by Antibody molecules. T cell epitopes are short peptides which are bound by major histocompatibility complexes (MHC) and subsequently recognized by T cells. A B cell epitope is a region of a protein, or other biomacromolecule, recognized by soluble or membrane-bound Antibodies.

Thus, antigenicity is the capacity, exhibited by an antigen, for recognition by one or several parts of the antibody or TCR immune repertoire. Immunogenicity, on the other hand, is the ability of an immunogen to induce a specific immune response when it is exposed to initial surveillance by the immune system. These two properties are clearly coupled but properly understanding how they are inter-related is by no means facile. Predicting actual antigenicity and/or immunogenicity of a complex protein remains problematic.

As we have said, MHCs bind peptides. These are themselves derived through the degradation, by protelotytic enzymes, of foreign and self proteins. Foreign epitopes originate from benign or pathogenic microbes, such as viruses and bacteria. Self epitopes originate from host proteins that find their way into the degradation pathway as part of the cell's intrinsic quality control procedures. The proteolytic pathway by which peptides become available to MHCs is very complex and many, many important details and molecular components remain to be elucidated.

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In Silico Immunology by Darren D.R. Flower, Jon Timmis


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