By Christoph W. Sensen
During this specific presentation of a innovative box of technology, the 1st part introduces the domain names of software for genomics and bioinformatics, resembling sequencing and the comparative series research of version organisms, investigating genetically motivated illnesses, the advance of recent energetic ingredients, agri-food and environmental genomics.
There then follows an summary of present issues imperative to DNA applied sciences, proteomics, metabolomics and bioinformatics, together with such sizzling themes as DNA chip fabrication, yeast hybrid research, instruments for gene expression reports, metabolic networks and platforms biology.
The complete is rounded off by means of 4 chapters at the moral, felony and social facets of this delicate subject.
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Extra info for Handbook of Genome Research, Two Volume Set: Genomics, Proteomics, Metabolomics, Bioinformatics, Ethical and Legal Issues
What started as the “phage family”, however, dramatically split into hundreds of individual groups working in tough competition. As one of the most important outcomes, sequencing of E. coli was performed more than once. Because of the separate efforts, the genome finished only as number seven [2–4]. The amount of knowledge acquired, however, is certainly second to none and the way this knowledge was acquired is interesting, both in the history of sequencing methods and bioinformatics, and because of its influence on national and individual pride.
1. Chronology of the most important primary detection and method applications with E. coli. 1886 1922 1940 1943 1947 “bacterium coli commune” by T. Escherich Lysogeny and prophages by d’Herelle Growth kinetics for a bacteriophage by M. Delbrück (Nobel prize 1969) Statistical interpretation of phage growth curve (game theorie) by S. Luria (Nobel prize 1969) Konjugation by E. Tatum and J. Lederberg (Nobel prize 1958) Repair of UV-damage by A. Kelner and R. Dulbecco (Nobel prize for tumor virology) DNA as the carrier of genetic information, proven by use of radioisotopes by M.
FELDMANN (Munich, Germany). S. cerevisiae has a long tradition in biotechnology and a long-term research history as a eukaryotic model organism per se. It was the first eukaryote to be completely sequenced and has led the way to sequencing other eukaryotic genomes. The wealth of the yeast’s sequence information as useful reference for plant, animal, or human sequence comparisons is outlined in the contribution. Among the plants, the small crucifer Arabidopsis thaliana was identified as the classical model plant, because of simple cultivation and short generation time.
Handbook of Genome Research, Two Volume Set: Genomics, Proteomics, Metabolomics, Bioinformatics, Ethical and Legal Issues by Christoph W. Sensen