By Brian H. Vickery, Bruno Lunenfeld (auth.), B. H. Vickery, B. Lunenfeld (eds.)
These 4 volumes comprising "GnRH Analogues in melanoma and Human replica" are a distillation of the displays of the invited audio system at a landmark overseas Symposium bearing an identical identify, geared up by way of considered one of us (B. L. ) and held in Geneva, Switzerland in February 1988. The Symposium used to be really interdisciplinary spanning gonadal hormone established ailment together with quite a few types of melanoma and varying to manage of fertility, either seasoned- and perception. The overseas taste might be stuck from the 480 contributors and 259 members drawn from 14 international locations. The Symposium, and consequently this ebook, do not have been attainable with out the backing of The foreign Committee for learn in copy and the sponsorship of the foreign Society of Gynecologic Endocrinology, The Swiss Society of Fertility and Sterility, The collage of Geneva institution of medication, The Swiss Society of Endocrinology and the U.S. beginning for reports in copy Inc. , and support from the area well-being association. B. H. Vickery B. Lunenfeld June 1989 record OF participants TO THE sequence H. Bartermann A. Abbondante First Institute of Obstetrics and Urologische Universitatsklinik Kiel Gynecology Arnold-Heller Strasse 7 collage "La Sapienza" D-2300 Kiel 1, FRG Rome,ltaly M. Bartholomew P. Abel division of Medicine/Endocrinology division of Urology Milton S. Hershey clinical heart Hammersmith health facility Pennsylvania nation college DuCane highway PO field 850, Hershey, PA 17033, united states London W12 OHS, united kingdom D. Beck H.
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Extra info for GnRH Analogues in Cancer and Human Reproduction: Volume IV Precocious Puberty, Contraception and Safety Issues
This dose reduces the castrationinduced high levels of LH and FSH , and blocks reproductive function in young male rats . After 8 weeks of treatment, a recovery period of 8 or 16 weeks was investigated. After 16 weeks of buserelin treatment, a recovery period of 8 weeks was studied. During and after treatment, hypothalamic, pituitary and testicular functions were monitored . Hypothalamic LHRH content was measured by specific RIA. The pituitary LHRH receptors were measured by specific binding of l25I-buserelin .
Sandow, J, Hahn, M, Krauss, Band Rechenberg, Wv (1983). Reproductive function male and female rats treated with luteinizing hormone releasing hormone agonist (buserelin) before puberty. In: Endocrine Society, 65th. Annual Meeting, June 8-10, 1983, Abstract 1262, 396 46. Belanger, A, Tremblay, Y, Lacoste, D, Giasson, M,Dupont, A and Labrie, F (1984). The dog, a good model for the study of LHRH agonists as blockers of androgen secretion and potential contraceptives. ) "LHRH and its Analogues". 141.
Ol 32 pituitary desensitization cannot be explained only on the basis of receptor loss (Fig. 6). Thus, it appears that a post-receptor defect is induced by chronic overstimulation with GnRH agonist which will affect LH biosynthesis. Stimulation with ovine LH did not elicit any T response in treated animals. This lack of response to LH stimulation can be closely correlated with the complete loss of specific LH receptors. CONCLUSIONS Oaily administration of either a GnRH agonist or a GnRH antagonist starting at 20 days of life produced delay of sexual maturation in the male rat, thus extending previous observations [26-30].
GnRH Analogues in Cancer and Human Reproduction: Volume IV Precocious Puberty, Contraception and Safety Issues by Brian H. Vickery, Bruno Lunenfeld (auth.), B. H. Vickery, B. Lunenfeld (eds.)