Download e-book for kindle: Genetics and Molecular Biology by Dr. Robert F. Schleif

By Dr. Robert F. Schleif

ISBN-10: 0801846730

ISBN-13: 9780801846731

ISBN-10: 0801846749

ISBN-13: 9780801846748

In the 1st variation of Genetics and Molecular Biology, well known researcher and award-winning instructor Robert Schleif produced a distinct and stimulating textual content that was once a outstanding departure from the traditional compendia of evidence and observations. Schleif's process was once to give the underlying basic ideas of molecular biology with transparent reasons and demanding research of well-chosen experiments. the outcome used to be a concise and useful process that provided scholars a true knowing of the topic. This moment version keeps that worthy approach--with fabric completely up to date to incorporate an built-in remedy of prokaryotic and eukaryotic molecular biology.

Genetics and Molecular Biology is copiously illustrated with two-color line paintings. every one bankruptcy contains an in depth checklist of significant references to the first literature, in addition to many leading edge and thought-provoking difficulties on fabric lined within the textual content or on comparable themes. those aid concentration the student's awareness of numerous serious concerns. ideas are supplied for half the problems.

Praise for the 1st edition:

"Schleif's Genetics and Molecular Biology... is a amazing fulfillment. it's a sophisticated textual content, derived from fabric taught principally to postgraduates, and should most likely be suggestion most suitable to budding pros in molecular genetics. In many ways this may be a pity, simply because there's additionally gold the following for the remainder of us... the teachings the following in facing the knowledge explosion in biology are that an oz. of reason is worthy a pound of evidence and that, for tutorial worth, there's not anything to overcome an writer writing approximately stuff he is familiar with from the inside."--Nature.

"Schleif provides a quantitative, chemically rigorous method of interpreting difficulties in molecular biology. The textual content is exclusive and obviously enhanced to any at present available."--R.L. Bernstein, San Francisco nation University.

"The maximum energy is the author's skill to problem the scholar to get entangled and get lower than the surface."--Clifford Brunk, UCLA

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Example text

Cells possess another remarkable enzyme. This enzyme, DNA gyrase or DNA topoisomerase II, adds negative superhelical turns; as expected, energy from the hydrolysis of ATP is required for this reaction. Studies of the activity of topoisomerases I and II, omega and gyrase, have shown that these enzymes can best be thought of as functioning by strand passage mechanisms. Where two DNA duplexes cross, gyrase, with the consumption of an ATP molecule, can permit the duplex lying below to be cut, to pass the first, and to be rejoined.

Yet another indication of the importance of supercoiling to cells is shown by the behavior of DNA topoisomerase I mutants. Such mutants grow slowly, and fastergrowing mutants frequently arise. These are found to possess mutations that compensate for the absence of the topoisomerase I by a second mutation that reduces the activity of gyrase, topoisomerase II. A third line of experimentation also suggests that the DNA in bacteria, but not eukaryotic cells, experiences an unwinding torsion from the linking number deficit.

Pettijohn, J. Bact. 173, 3047-3059 (1991). Characterization of the Cytoplasm of Escherichia coli as a Function of External Osmolarity, S. Cayley, B. Lewis, H. Guttman, M. , J. Mol. Biol. 222, 281-300 (1991). Estimation of Macromolecule Concentrations and Excluded Volume Effects for the Cytoplasm of Escherichia coli, S. Zimmerman, S. Trach, J. Mol. Biol. 222, 599-620 (1991). Inside a Living Cell, D. Goodsell, Trends in Biological Sciences, 16, 203-206 (1991). Nucleic Acid and Chromosome Structure 2 Thus far we have considered the structure of cells and a few facts about their functioning.

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Genetics and Molecular Biology by Dr. Robert F. Schleif


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