Read e-book online Drug Resistance in Cancer Cells PDF

By Gergely Szakács, Kenneth Kin Wah To, Orsolya Polgár (auth.), Zahid H. Siddik, Kapil Mehta (eds.)

ISBN-10: 0387894446

ISBN-13: 9780387894447

An anticipated 1.5 million sufferers within the usa are clinically determined with melanoma each year and over half-a-million members die of the sickness. because the overwhelming majority of the deaths happen after scientific intervention with anticancer treatment, either traditional chemotherapy and novel exact treatment, it may be concluded that those sufferers die from drug resistant cancers. an increasing number of stories have printed that mechanisms underlying the advance of drug resistance in melanoma cells are manifold and intricate and intensely most probably are depending on mobilephone and microenvironment context. In view of those proof, it is very important record the mechanisms of drug resistance and comprehend that are the dominant resistance pathways in a selected tumor kind which may supply power healing goals in a scientific surroundings.
This e-book serves as a unmarried resource for the present wisdom on genetic and epigenetic adjustments that give a contribution to the advance of drug resistance. finished experiences written by means of well known specialists offer nice perception at the present wisdom on drug resistance mechanisms. This publication is a prepared resource of knowledge to clinicians, mobilephone and melanoma biologists and defines molecular drug resistance mechanisms which are tough scientists and medical oncologists today.

About Editors:
Dr. Kapil Mehta is a Professor within the division of Experimental Therapeutics, The college of Texas M. D Anderson melanoma middle, Houston, TX. He has released broadly and got a number of patents on novel discoveries when it comes to drug resistance within the box of melanoma therapeutics.
Dr. Zahid H. Siddik is usually a Professor within the division of Experimental Therapeutics on the college of Texas M.D. Anderson melanoma heart. He has studied generally the mechanisms of drug motion and resistance, and is famous for his seminal stories with platinum-based antitumor agents.

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Wada, et al. (2000). ” Clin Cancer Res 6(12): 4618–27. To, K. , O. Polgar, et al. (2008). ” Mol Cancer Res 6(1): 151–64. To, K. , Z. Zhan, et al. (2006). ” Mol Cell Biol 26(22): 8572–85. To, K. , Z. Zhan, et al. (2008). ” Mol Cell Biol 28(17): 5147–61. , H. Iida, et al. (1981). ” Cancer Res 41(5): 1967–72. Turner, J. , J. L. Gump, et al. (2006). ” Blood 108(12): 3881–9. , E. Stahl, et al. (2005). “BCRP mRNA expression v. ” Leuk Res 29(2): 141–6. , B. Lowenberg, et al. (2005). ” Blood 106(8): 2646–54.

Q. Chen, et al. (2002). ” J Biol Chem 277(46): 44268–77. , S. Itagaki, et al. (2005). ” Biosci Biotechnol Biochem 69(10): 1871–6. , H. Wu, et al. (2008). ” Biochem Pharmacol. Zhu, Q. and M. S. Center (1994). ” Cancer Res 54(16): 4488–92. Zhu, Q. and M. S. Center (1996). ” DNA Cell Biol 15(2): 105–11. Chapter 2 Metastasis and Drug Resistance Dominic Fan, Sun-Jin Kim, Robert L. Langley, and Isaiah J. Fidler Abstract Multidrug resistance (MDR) phenotype emerging from chemotherapy is a major problem in managing patients with metastatic cancers.

1998). ” Br J Cancer 77(4): 627–31. , Q. Chen, et al. (2002). ” J Biol Chem 277(46): 44268–77. , S. Itagaki, et al. (2005). ” Biosci Biotechnol Biochem 69(10): 1871–6. , H. Wu, et al. (2008). ” Biochem Pharmacol. Zhu, Q. and M. S. Center (1994). ” Cancer Res 54(16): 4488–92. Zhu, Q. and M. S. Center (1996). ” DNA Cell Biol 15(2): 105–11. Chapter 2 Metastasis and Drug Resistance Dominic Fan, Sun-Jin Kim, Robert L. Langley, and Isaiah J. Fidler Abstract Multidrug resistance (MDR) phenotype emerging from chemotherapy is a major problem in managing patients with metastatic cancers.

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Drug Resistance in Cancer Cells by Gergely Szakács, Kenneth Kin Wah To, Orsolya Polgár (auth.), Zahid H. Siddik, Kapil Mehta (eds.)


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