By Ching-Hon Pui
Adolescence leukemias symbolize approximately one 3rd of all cancers in childrens and current a distinct problem to oncologists, pediatricians, hematologists, and different wellbeing and fitness execs. Ching-Hon Pui has assembled knowledgeable workforce of authors to increase the main complete, clinically-oriented, and authoritative reference devoted to those illnesses. the amount strikes from the laboratory bench to the sufferer bedside in 4 easily-accessible sections. totally referenced and up to date, it really is an absolute 'must-have' for any surgeon or investigator who bargains with leukemias in formative years.
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Additional info for Childhood Leukemias
It concludes with comments about the lessons taught by this history. Description of leukemia Although the first description of a patient with leukemia was published in 1827,2 it was not until 1845 that Virchow3 in Germany (Fig. 6 He distinguished leukemia from leukocytosis and described two types: splenic, associated with splenomegaly, and lymphatic, associated with large lymph nodes and cells in the blood resembling those in the lymph nodes. He also proposed his cellular theory of the origin of leukemia, a concept basic to current understanding of the disease.
Not only did his work result in today’s highly successful neonatal screening programs, but 45 years later stored “Guthrie spots” are used to track fetal origins of leukemia. Good research benefits all eventually. There is an anecdote that an accomplished senior leukemia researcher was asked by a site visit committee for his 5-year plan. He is said to have responded: “Five years? I don’t know what I will do this afternoon. ” REFERENCES 1 Aur, R. J. , Simone, J. , Hustu, H. , et al. Central nervous system therapy and combination chemotherapy of childhood lymphocytic leukemia.
182 By the late 1940s, blood transfusions together with the newly available antibacterial agents became generally accepted as a way of maintaining life while families tried to adapt to the prognosis and begin their grieving. 183,184 This resulted in a remarkable reduction in hemorrhage as a cause of death. Platelet transfusions also provided time for antileukemic drugs to produce remission, especially in patients with AML, leading to increased rates of remission induction. Finally, the availability of platelet transfusions allowed administration of higher or more prolonged dosages of hematosuppressive agents because one could tide patients through periods of drug-induced thrombocytopenia.
Childhood Leukemias by Ching-Hon Pui