By Georges Mathé MD (auth.)
I wish to thank all my co-workers who've collaborated with me, from 1963 previously, in organic and medical learn within the box of melanoma lively immunotherapy, of its immuno prevention and immunorestoration. they are going to usually be quoted during this e-book. i'm rather thankful to people who have helped me to write down it by means of reviewing a few chapters: D. BELPOMME, J. F. DOR~, IRENE FLORENTIN, A. GOUTNER, I. J. Hm, R. HUCHET and MARIE-CHRISTINE SIMMLER. I additionally thank NICOLE VRIZ, MARIE-CLAUDE SCHNEIDER, FENELLARIsELEY and M. JUVET for his or her keen and effective co-operation within the preperation of the manuscript. i'm ultimately thankful to all authors of books or articles who approved me to breed their figures or tables. Paris, April 1976 G. MAT~ Contents bankruptcy 1. advent and Definitions 1 bankruptcy 2. organic foundation: Tumour linked Antigens, the Immune equipment and Its Behaviour relating melanoma Cells five 2. 1. Tumour-Associated Antigens five 2. 2. The Immune equipment 19 2. 2. 1. Humoral Mediated Immunity and telephone Mediated Immunity 19 2. 2. 2. T- and B-Lymphocyte and Monocyte Differen tiation 22 2. 2. three. T-Lymphocyte features 25 2. 2. four. B-Lymphocyte services 30 2. 2. five. Macrophage features 31 2. 2. 6. K-Cell functionality 32 2. three. The Immune equipment and melanoma Cells 33 2. three. 1. Mechanisms fascinated with Tumour mobilephone Rejec tion 33 2. three. 1. 1. In vivo proof for Tumour Immunity 33 2. three. 1. 2.
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Additional info for Cancer Active Immunotherapy: Immunoprophylaxis and Immunorestoration
Control lymphocytes - ~. '. , . ;••.. ~ ...... " :' . '. ' . ~~ g _. '. . . _• ':':' ' '. ~ ......... ~ . ..... '" . ~;:':: .... - Patient's Iymphacytes ___ ©,~; :: . 8 . - Patient's serum l"':, , ... '. 20. Hellstrom's test demonstrating what were considered to be blocking factors in sera of cancer patients 50 1969). Hyperimmune sera against tumour alloantigens or tumour-associated antigens could block, in vitro, lymphocyte-mediated cytotoxicity after incubation with the specific target cells, but not with the effector lymphocytes (efferent blocking) (MOLLER, 1965; BALDWIN and BARKER, 1967; BRUNNER eta l.
Enhancement of isogeneic tumour growth has also been observed after treatment with hyperimmune sera directed against tumour-associated antigens (M5LLER. 1964; BUBENIK and KOLDOVSKY. 1965; BATCHELOR. 1968). Nevertheless. this work did not receive much attention until there was growing evidence to show that tumour-bearing hosts have factors in their serum which specifically inhibit cellular immunity against tumour cells in vitro; this argues for the role of enhancement in the development of autochthonous tumours (HELLSTR5M and HELLSTR5M.
1966; MILLER and MITCHELL, 1968). A third type of mononuclear cells, which belongs to the monocyte series, participates in immunological reactions, either at an early stage in the cellular sequence resulting in antibody formation, and/or as nonspecific effector cells of cell-mediated immunity (Fig. 7). ~Antigen activation~. • · . '-; _6a! TLc •• \m\t ~~~~ l•• -'V. Lc e • • 9. , positive collaboration •. / .. • sUC)pressor function Fig. 7. 1. Moc = Monocyte, 2. Nonactivated MpH = Nonactivated macrophage, 3.
Cancer Active Immunotherapy: Immunoprophylaxis and Immunorestoration by Georges Mathé MD (auth.)