By L. Rosenberger, D. J. Triggle (auth.), George B. Weiss (eds.)
Anyone surveying physiological and pharmacological journals can without difficulty see that the organic activities of calcium ion are of more and more frequent present curiosity. The scope of investi gated activities and reactions during which a task for calcium ion is of a few significance is so a variety of as to express the impact that calcium ion is in all places and interacts with every thing. This being so, the problem in modern examine is to target research of these activities of calcium ion which, in a few demeanour, effect both major physiological parameters or the way during which pharmacological brokers act. This multi-authored e-book originated from a extra constrained Symposium on "Importance of Calcium as a main Locus of Drug motion" co-chaired alone and Dr. Frank R. Goodman on the April, 1977 FASEB assembly in Chicago. This Symposium was once geared up in line with a perceived desire for elevated communique between 2 employees in numerous components of Ca +-related examine. within the seasoned cess of choosing the utmost of six parts for presentation in the structure supplied, it quickly turned obvious that this might bring about just a constrained sampling of present learn efforts. enlargement of the variety of parts to 14 inside a ebook structure looked to be the main logical mechanism to supply a extra coherent inter disciplinary method of attention of assorted features of the two roles of Ca + in drug motion. this isn't to indicate that each one rele 2 vant Ca +-related parts are surveyed inside this volume.
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Additional resources for Calcium in Drug Action
Pressmen, B. , 1974, The activation of sea-urchin eggs by the divalent cation ionophores A23l87 CALCIUM ENTRY AND ANTAGONISTS 25 and X-537A, Biochem. Biophys. Res. Commun. 60: 126. Cochrane, D. , and Douglas, W. , 1974, Calcium-induced extrusion of secretory granules (exocytosis) in mast cells exposed to 48/80 or the ionophores A-23l87 and X-537A, Proc. Nat. Acad. Sci. A. 71: 408. Cochrane, D. , Douglas, W. , 1975, Calcium and stimulus-secretion coupling in the adrenal medulla: contrasting stimulating effects of the ionophores X-537A and A23l87 on catecholamine output, J.
1975) showed that 1 ~g/ml of verapamil specifically inhibited the low affinity Ca 2 + binding and had little effect on the high affinity Ca binding. In isolated rat sarcolemmal membranes La 3 + was also found to inhibit only the low-affinity Ca 2 + binding sites. The evidence, while indirect, suggests that cardioactive drugs such as digitalis and verapamil have their known effp_ts on myocardial contractility by induction of perturbations ~_" the superficially bound Ca 2 +. Nayler et al. (1976), in a series of studies set out to investigate this possibility for glycoside and verapamil using La 3 + as a probe.
Douglas, W. , 1968, Stimulus-secretion coupling: the concept and clues from chromaffin cells, Brit. J. Pharmacol. 34: 451. Douglas, W. , 1974, Involvement of calcium in exocytosis and the exocytosis-vesiculation sequence, Biochem. Soc. Symp. 39: 1. Dreifuss, J. , Grau, J. , and Nordmann, J. , Calcium movements related to neurohypophysial hormone secretion, in "Calcium Transport in Contraction and Secretion" (E. Carafoli, F. Clementi, W. ), pp. 271-279, North-Holland Publishing Company, Amsterdam.
Calcium in Drug Action by L. Rosenberger, D. J. Triggle (auth.), George B. Weiss (eds.)