Download e-book for kindle: Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy: by Christopher D. Gregory

By Christopher D. Gregory

ISBN-10: 3319394045

ISBN-13: 9783319394046

ISBN-10: 3319394061

ISBN-13: 9783319394060

This ebook discusses houses of apoptosis and different telephone dying modalities in melanoma pathogenesis and therapy. Its 9 chapters talk about modulation of anti-tumor inflammatory and immune responses, results at the tumor microenvironment, to recommendations for bettering pro-apoptotic remedies, mechanisms and implications for illness pathogenesis, axl and mer receptor tyrosine kinases, immunogenic apoptotic cellphone loss of life and anti-cancer immunity and melanoma mobilephone death-inducing radiotherapy. This booklet areas the onco-biology of apoptosis in transparent and aim point of view via an expertly synthesized sequence of reviews.
Apoptosis in melanoma Pathogenesis and Anti-cancer Therapy is a deft and thorough exploration of state of the art examine in apoptosis and anti-cancer mechanisms from easy biology to oncology. It highlights a swiftly growing to be box inside melanoma study and is vital studying for oncologists, biochemists and complex graduate scholars alike.

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Additional info for Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy: New Perspectives and Opportunities

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34. Strasser A, et al. Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2. Nature. 1990;348(6299):331–3. 35. Beverly LJ, Varmus HE. MYC-induced myeloid leukemogenesis is accelerated by all six members of the antiapoptotic BCL family. Oncogene. 2009;28(9):1274–9. 36. McDonnell TJ, et al. bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell. 1989;57(1):79–88. 37. Biswas S, et al. A role for proapoptotic Bax and Bak in T-cell differentiation and transformation.

Leukemia. 2012;26(6): 1293–300. 179. Vucur M, et al. RIP3 inhibits inflammatory hepatocarcinogenesis but promotes cholestasis by controlling caspase-8- and JNK-dependent compensatory cell proliferation. Cell Rep. 2013;4(4):776–90. 180. Schmidt SV, et al. RIPK3 expression in cervical cancer cells is required for PolyIC-induced necroptosis, IL-1alpha release, and efficient paracrine dendritic cell activation. Oncotarget. 2015;6(11):8635–47. 181. Melo-Lima S, Celeste Lopes M, Mollinedo F. Necroptosis is associated with low procaspase-8 and active RIPK1 and -3 in human glioma cells.

Kaiser WJ, et al. Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL. J Biol Chem. 2013;288(43):31268–79. 157. Thapa RJ, et al. Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases. Proc Natl Acad Sci U S A. 2013;110(33):E3109–18. 158. Linkermann A, et al. Dichotomy between RIP1- and RIP3-mediated necroptosis in tumor necrosis factor-alpha-induced shock. Mol Med. 2012;18:577–86. 159. Lukens JR, et al. RIP1-driven autoinflammation targets IL-1alpha independently of inflammasomes and RIP3.

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Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy: New Perspectives and Opportunities by Christopher D. Gregory


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