Download e-book for kindle: Antisense Therapeutics by Sudhir Agrawal

By Sudhir Agrawal

ISBN-10: 0896033058

ISBN-13: 9780896033054

Best researchers supply an authoritative survey and research of the newest findings at the speedy improvement of antisense oligonucleotides healing and their software in quite a few in vivo version platforms. The book's high-profile individuals supply well timed debts in their state of the art innovations, discussing such themes because the synthesis and purification of oligonucleotides, their choice for a selected gene goal, assorted tools of management, and using quite a few mobilephone traces and cellphone tradition platforms. in addition they research questions of mobile uptake, in vitro organic job, in vivo organic job, the pharmacology and pharmacokinetics of oligonucleotides, and the appliance of oligonucleotides to the relevant worried procedure.

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Tonkinson, J L , and Yakubov, L. (1991) Phosphorothtoate ohgodeoxynucleottdes-anttsense inhibitors of gene expression? , Matteucci, M. , and Martm, J. C. (1993) Current concepts in antisense drug design J Med Chem 36, 1923-1937. Stem, C A. -C (1993) Antisense oligonucleottdes as therapeuttc agents-Is the bulllet really magical? , and Neckers, L. M. 343-350. 42 Bennett et al. 14 KitaJima, I , Shmohara, T , Btlakovics, J , Brown, D A , Xu, X , and Nerenberg, M (1992) Ablation of transplanted HTLV-1 tax-transformed tumors m mace by antisense mhibitton of NF-kB Sczence 258, 1792-I 795 15.

And Crooke, S (1993) Disposition of the 14C-labeled phosphorothtoate ohgonucleottde ISIS 2105 after intravenous admmlstratton to rats J Pharmacol Exp Ther 267, 1181-l 190. Cossum, P A, Truong, L , Owens, S. , and Crooke, S T (1994) Pharmacokinettcs of a 14C-labeled phosphorothtoate ohgonucleottde, ISIS 2105, after intradermal admimstratton to rats. J. Pharmacol Exp Ther 269,89-94 Agrawal, S , Temsamam, J , and Tang, J Y (1991) Pharmacokmettcs, btodistrtbutron, and stabthty of ohgodeoxynucleottde phosphorothtoates m mice.

1994) Pharmacokinettcs, tissue distrtbution, and stabtllty of antisense ohgodeoxynucleottde phosphorothioate ISIS 3466 m mace Oncol Res 6,243-249 Crooke, S T (1993) Therapeutic potential of oligonucleotides. Cur-r Oprn Znvest Drugs 2, 1045-1048. Crooke, S. T (1992) Therapeutic applicatrons of ohgonucleotides Annu Rev Pharmacol Toxic01 32, 329-376. Calabretta, B. (1991) Inhibition of protooncogene expression by antisense ohgodeoxynucleottdes btological and therapeutic implications. Cancer Res 51, 4505-4510.

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Antisense Therapeutics by Sudhir Agrawal

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