By Kjell Öberg, Gunnar Alm (auth.), Huub Schellekens (eds.)
This e-book, written through top authors within the box, is the 1st to house all points of cytokine antibodies, from attempt method and standardization to organic outcomes and features. It encompasses antibodies precipitated via cytokines used therapeutically and antiviral antibodies. to appreciate the biology, the consequences of cytokine antibodies in experimental animal versions and sufferers also are mentioned. The booklet is meant for researchers of cytokine biology, pharmaceutical businesses constructing cytokines and cytokine antibodies as cures, and clinicians attracted to modulating the immune method as therapy.
Read or Download Antibodies in Cytokines: The concerted action on the antigenicity of rDNA derived pharmaceuticals PDF
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This publication, written through best authors within the box, is the 1st to accommodate all points of cytokine antibodies, from try out method and standardization to organic results and features. It encompasses antibodies brought about by way of cytokines used therapeutically and antiviral antibodies. to appreciate the biology, the results of cytokine antibodies in experimental animal versions and sufferers also are mentioned.
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Extra resources for Antibodies in Cytokines: The concerted action on the antigenicity of rDNA derived pharmaceuticals
KAPOSI'S SARCOMA (KS) IFN--y induces normal endothelial cells to acquire the phenotype of KS cells. KS lesions blocked by mABs anti-IFN-T flow cytometric assay [17-18]. It remains yet unclear why the neutralizing effects of the immunoglobulins disappeared 13 days after infection, but this may be related either to preferential consumption of the neutralizing antibodies, to a switch in the epitope antibody repertoire or to an altered ratio of cytokine neutralizing to cytokine enhancing antibodies .
15. 16. References 1. 2. 3. 4. 5. 6. , Schyberg, T. and Berg, K 1990. Autoantibodies to crude human leukocyte interferon (IFN), native human IFN-,B, recombinant human IFN-a2b and human IFN-"'( in healthy blood donors. Clin. expo Immunol. 82: 57-62. , Sereni, D. and Varet, B. 1981. Patient with circulating antibodies to (leinterferon. Lancet 11,1227-1228. , Ross. C. and Svenson, M. 1994. Naturally occurring autoantibodies to interleukin-I (le, interleukin-6, interleukin-IO and interferon-a. J. Interferon Res.
5. 6. 7. 8. 9. 10. II. 12. to IFN-')' in man and their increase during viral infection. J Immunol 1990; 144: 685-690. Viani E, F1amminio G, Caruso A, Foresti I, De Francesco M, Pollara P, Balsari A, Turano A. Purification of natural human IFN-')' antibodies. Immunol Lett 1991; 30: 53-58. Turano A, Balsari A, Viani E, Landolfo S, Zadoni L, Gargiulo F, Caruso A. Natural human antibodies to ')' interferon interfere with the immunomodulating activity of the Iymphokine. A. 1992; 89: 4447-4451. Jung V, Rashidbaigi A, Jones C, Tischfelt JA, Sows TB, Petska S.
Antibodies in Cytokines: The concerted action on the antigenicity of rDNA derived pharmaceuticals by Kjell Öberg, Gunnar Alm (auth.), Huub Schellekens (eds.)