By C. D. Kochakian (auth.), Charles D. Kochakian Ph.D. (eds.)
This quantity used to be deliberate to supply a finished survey of the position of the anabolic-androgenic steroids within the very important economic climate unique of the androgenic (sexual) capabilities. It appeared applicable to compile all of this knowledge in an equipped model in a single quantity at present not just to function a resource of data but in addition to point and recommend parts that want extra exploration. The anabolic motion of the steroid hormones has undergone a interval of serious job in either easy and scientific learn. a whole realizing of the manifold anabolic results nonetheless continues to be elucidated and the artwork of scientific program is simply steadily turning into obvious. This quantity may be worthy not just to the skilled investigator in either simple and scientific examine but additionally for the amateur. additionally, it's going to function a resource of data for the cautious use of those steroids in sure metabolic ailments. those steroids have had huge scientific program with variable effects. typically additional cautious exploration is advised. different cases have verified various levels of usefulness.
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Additional resources for Anabolic-Androgenic Steroids
17a-Methyl-5a-androstan-17j3-o1 was completely ineffective in stimulating the kidney and accessory sex organs of the castrated mouse when implanted subcutaneously as a pellet because of its lack of absorption. When it was administered orally, it was more effective than 17a-methyltestosterone in inducing growth of the kidney and less effective on the accessory sex organs (KOCHAKIAN, 1952). There is one unexplained major inconsistency. , 1963c). No explanation could be provided 1. Another laboratory (TOMARELLI and BERNHART, 1964), however, was in agreement with the two earlier studies.
After 30 days of repletion, 2 of 8 control (oil) and 8 of 16 testosterone propionate-treated rats were dead. The surviving treated rats increased their body weights slightly more than that of the controls and also ingested slightly more food. The rats of neither group attained the weight of rats on an 18% casein diet. The high mortality of the treated rats might be due to aggravation of the sulfur amino acid deficiency of the 7% casein diet by the protein-anabolic demands of the testosterone propionate.
KOCHAKIAN female than in the castrated male dog. Blood glucose, NPN, and fat were not affected in the above experiments. SIREK and BEST (1953) also did not detect an effect on blood glucose of normal female dogs after injection of testosterone propionate. 3. Monkey STUCKI et al. (1960) developed a quantitative bioassay method using metabolic balance studies in the ovariectomized young female monkey (M acaca mulatta). Although considerable scatter was obtained in the individual data, the average values gave a log-dose response not only for nitrogen retained, but also for potassium retention and increase in body weight.
Anabolic-Androgenic Steroids by C. D. Kochakian (auth.), Charles D. Kochakian Ph.D. (eds.)